Carol Ann Susi, born February 2, 1952, was best known the voice of Mrs. Wolowitz on The Big Bang Theory. We never saw her but no one will ever forget her raspy, Jewish-laden tone. Unfortunately, she passed away in 2014 from cancer. The producers of The Big Bang Theory chose to have Mrs. Wolowitz die on the show rather than replace her.
I think we all agree there could be no replacement for Ms. Susi!