Betty Boop debuts 1930

Betty Boop made her first appearance in Dizzy Dishes, August 9, 1930. She was created by at Fleischer Studios and released by Paramount Pictures.  Between 1930 and 1939, she was featured in 90 cartoons. Mae Questel provided the voice of Betty from 1931 on and she recreated the voice for Betty Boop in the movie Who Framed Roger Rabbit?

In 2002, she was ranked #17 in TV Guide's 50 greatest cartoon characters of all time

First appearance of Wile E. Coyote and the Road Runner 1949

Chuck Jones premiered Fast and Furry-ous, the first appearance of the comic duo Wile E. Coyote and the Road Runner, September 17, 1949.  Jones meant the couple to be a parody of cartoon characters Tom and Jerry. As of 2020, fifty cartoons have been made feature the characters.

TV Guide listed Wile E. Coyote as one of the 60 Nastiest Villains of All Time in 2013.